![]() This review provides a specific overview on Co–Cr dental alloys in terms of metal ions and wear particles release, toxicological risks, and the actual and new EU regulatory framework. In this context, the use of Co might be forbidden if the medical devices are invasive and as soon as they include more than 0.1% (m/m) Co. On 18 February 2020, the 14th Adaptation to Technical Progress (ATP14) to the Classification, Labelling and Packaging (CLP) regulation was published, including the harmonised classification for Co metal as a CMR 1B substance. A new EU Medical Devices Regulation (MDR) (2017/745) will be applied in May 2021 with the need to consider that Co metal is a new carcinogenic, mutagenic and toxic to reproduction (CMR) substance. Machine Prospector a library of predictive models that interrogates TerraShedSM to identify previously unknown mineral. Since 2017, the European Union (EU) regulatory framework for Co–Cr alloys has been undergoing profound changes. KoBold has developed two proprietary platforms to power discovery: TerraShedSM, a comprehensive data system aggregating and structuring more than a century’s worth of data from around the world and. Furthermore, the links between exposure and the appearance of local or systemic toxicity are not automatic. Toxicological studies following Co and Cr exposures in the oral cavity are more difficult to conduct because there are many different situations leading to the release of metal ions and wear particles. ![]() ![]() There are quite meaningful data on the corrosion and toxicity of Co–Cr alloys for their use in restorative materials such as dental prostheses. Their success is mainly due to their mechanical properties such as stiffness, strength and corrosion resistance, thus allowing a high biocompatibility. Among existing examples, cobalt–chromium (Co–Cr) alloys increasingly began to be used in medicine and especially in dentistry. During the 20th century, metal alloys have assumed an important role as restorative materials. Cobalt salts are produced by dissolving cobalt metal in hydrochloric acid containing a small amount of thiosulfate ions. ![]()
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